RX 6600 vs GTX 1080 Ti

The RX 6600 and GTX 1080 Ti land at effectively the same price so your decision should come down to features, ecosystem fit, and availability rather than budget.

Power consumption is a meaningful differentiator here: the RX 6600 draws 132 W versus 250 W for the GTX 1080 Ti. That 118 W gap can determine whether your existing PSU is sufficient and will show up in long-term electricity costs.

As an NVIDIA card, the GTX 1080 Ti gives you access to DLSS 4 super-resolution and Frame Generation, which can meaningfully lift frame rates in supported titles. The RX 6600 counters with FSR 4, which is open-source and works across a wider range of games — including some that don't support DLSS. Which ecosystem matters more depends on the games in your library.